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Naturally occurring GLP-1 is produced primarily two different locations in the body, the gut and the brain. Much of the previous research in this field has, on the former at the expense of the latter focused in accessing the relevant population of GLP – 1 receptors, which mediate the suppression of food intake by pharmaceutical GLP-1 drugs can be identified. – Identifying both the site-of – action and mechanisms that accounts for the body weight loss of these GLP-1 drugs puts us one step closer to developing effective, FDA-approved treatments for obesity, said Hayes.Add rats or mice, the group saw the Baram that the release of CRH hippocampus, in the brain primary learning and memory center to the rapid disintegration of these dendritic spines that in turn collecting the capability of synapses and limits form memories store memories.